RIDA®QUICK Rotavirus/Adenovirus, cassette

Clinical trial will investigate whether ganciclovir can prevent the infection from spreading and decrease the number of days of viral shedding. Topical ganciclovir works by penetrating the infected cell and preventing the viral DNA from replicating,

The objective of this study was to compare the clinical sensitivity and specificity of the AdenoPlus™ test with those of both viral cell culture (CC) with confirmatory immunofluorescence assay (IFA) and polymerase chain reaction (PCR) at detecting the presence of adenovirus in tear fluid. AdenoPlus™ is a very sensitive and specific point-of-care diagnostic test to assist in the confirmation of adenoviral conjunctivitis and lead to the initiation of appropriate management of the disease in a timely manner. When compared only with CC-IFA, AdenoPlus™ showed a sensitivity of 90% (28/31) and specificity of 96% (93/97). When compared only with PCR, AdenoPlus™ showed a sensitivity of 85% (29/34) and specificity of 98% (89/91). When compared with both CC-IFA and PCR, AdenoPlus™ showed a sensitivity of 93% (27/29) and specificity of 98% (88/90). When compared with PCR, CC-IFA showed a sensitivity of 85% (29/34) and specificity of 99% (90/91).

The goal of this study was to compare the sensitivity, specificity, and accuracy of the RPS Adeno Detector in a clinical setting with viral cell culture for detecting adenoviral conjunctivitis. An additional objective of the study was to evaluate the ease of use and the applicability of the RPS Adeno Detector in the clinical routine of a physician’s office. Compared with CC-IFA, the RPS Adeno Detector was 88% sensitive and 91% specific at detecting adenoviral conjunctivitis. Using PCR as a reference method, the sensitivity of the RPS Adeno Detector increased to 89% and the specificity increased to 94%.